Abstract
Resistance to antifungals is a leading concern in the treatment of human mycoses. We demonstrate that the salA gene, encoding salicylate 1-monooxygenase, is involved in resistance of the dermatophyte Trichophyton rubrum to terbinafine, one of the most effective antifungal drugs against dermatophytes. A strain with multiple copies of salA was constructed and exhibited elevated expression of salA and increased terbinafine resistance. This reflects a mechanism not yet reported in a pathogenic fungus.
MeSH terms
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Antifungal Agents / pharmacology
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Drug Resistance, Fungal / drug effects
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Drug Resistance, Fungal / genetics*
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Genes, Fungal / genetics
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Microbial Sensitivity Tests
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Mixed Function Oxygenases / genetics*
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Mixed Function Oxygenases / metabolism*
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Terbinafine / pharmacology*
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Transcription, Genetic
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Transformation, Genetic
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Trichophyton / drug effects*
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Trichophyton / enzymology
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Trichophyton / genetics*
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Up-Regulation / genetics
Substances
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Antifungal Agents
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Mixed Function Oxygenases
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salicylate 1-monooxygenase
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Terbinafine