Updates in Postmastectomy Radiation

Jean L Wright; Arti Parekh

doi:10.1016/j.soc.2017.01.010

Updates in Postmastectomy Radiation

Surg Oncol Clin N Am. 2017 Jul;26(3):383-392. doi: 10.1016/j.soc.2017.01.010.

Authors

Jean L Wright¹, Arti Parekh²

Affiliations

¹ Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Suite 1440, 401 North Broadway, Baltimore, MD 21231, USA. Electronic address: jwrigh71@jhmi.edu.
² Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Suite 1440, 401 North Broadway, Baltimore, MD 21231, USA.

PMID: 28576178
DOI: 10.1016/j.soc.2017.01.010

Abstract

Although the use of postmastectomy radiation therapy (PMRT) is widely accepted in certain clinical situations, areas of controversy persist for some clinical scenarios. In addition, with significant shifts in the management of breast cancer, including omission of axillary nodal dissection in select sentinel node-positive patients and increased use of neoadjuvant chemotherapy, new clinical challenges have arisen regarding the role of PMRT. This article reviews the data to support current recommendations for postmastectomy radiation and explores areas of controversy and the studies that guide clinicians in these scenarios.

Keywords: Clinical risk factors; Locoregional failure; Mastectomy; Postmastectomy; Radiation.

Publication types

Review

MeSH terms

Breast Neoplasms / radiotherapy*
Breast Neoplasms / surgery*
Female
Humans
Lymph Node Excision
Lymphatic Metastasis / radiotherapy*
Mastectomy*
Neoadjuvant Therapy*
Neoplasm Metastasis
Neoplasm Recurrence, Local
Radiotherapy, Adjuvant / methods*
Treatment Outcome