The Complete Genome Sequence of a Human Parechovirus from a Child with Diarrhea in China Revealed Intertypic Recombination

Xiaoying Zhao; Chenglin Zhou; Xiaodan Zhang; Wang Li; Xinyu Wan; Yan Wang; Yuming Zeng; Wen Zhang

doi:10.1128/genomeA.00332-17

The Complete Genome Sequence of a Human Parechovirus from a Child with Diarrhea in China Revealed Intertypic Recombination

Genome Announc. 2017 May 25;5(21):e00332-17. doi: 10.1128/genomeA.00332-17.

Authors

Xiaoying Zhao¹, Chenglin Zhou², Xiaodan Zhang³, Wang Li², Xinyu Wan¹, Yan Wang¹, Yuming Zeng¹, Wen Zhang⁴

Affiliations

¹ Department of Microbiology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.
² Department of Laboratory Medicine, Jiangsu Taizhou People's Hospital, Taizhou, Jiangsu, China.
³ The Zhenjiang Center for Disease Control and Prevention, Zhenjiang, Jiangsu, China.
⁴ Department of Microbiology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China z0216wen@yahoo.com.

Abstract

A human parechovirus (HPeV), CH-ZXY1, was detected in feces from a child with diarrhea. Phylogenetic trees over three different genomic regions revealed discordant topological structures. Recombination analysis indicates that CH-ZXY1 is a recombinant resulting from recombination between HPeV5 and HPeV1, which was confirmed by PCR covering the recombination breakpoint.