Vibrational spectroscopic mapping and imaging of tissues and cells

Elizabeth A Carter; Koman K Tam; Robert S Armstrong; Peter A Lay

doi:10.1007/s12551-009-0012-9

Vibrational spectroscopic mapping and imaging of tissues and cells

Biophys Rev. 2009 Jul;1(2):95-103. doi: 10.1007/s12551-009-0012-9. Epub 2009 Jun 23.

Authors

Elizabeth A Carter¹, Koman K Tam^{1

2}, Robert S Armstrong¹, Peter A Lay³

Affiliations

¹ Vibrational Spectroscopy Facility, School of Chemistry, The University of Sydney, Sydney, NSW, 2006, Australia.
² Analytical Technologies Division-Biolab (Aust) Pty Ltd, 5 Caribbean Drive Scoresby, 3179, Victoria, Australia.
³ Vibrational Spectroscopy Facility, School of Chemistry, The University of Sydney, Sydney, NSW, 2006, Australia. p.lay@chem.usyd.edu.au.

Abstract

Vibrational spectroscopic mapping (point-by-point measurement) and imaging of biological samples (cells and tissues) covering Fourier-transform infrared (FTIR) and Raman spectroscopies has opened up many exciting new avenues to explore biochemical architecture and processes within healthy and diseased cells and tissues, including medical diagnostics and drug design.

Keywords: Biological tissues; Cells; Imaging; Mapping; Vibrational spectroscopy.

Publication types

Review