Durable Response to Afatinib in Lung Adenocarcinoma Harboring NRG1 Gene Fusions

J Thorac Oncol. 2017 Aug;12(8):e107-e110. doi: 10.1016/j.jtho.2017.04.025. Epub 2017 May 10.

Authors

Nathan D Gay¹, Ying Wang², Carol Beadling², Andrea Warrick², Tanaya Neff², Christopher L Corless², Khaled Tolba³

Affiliations

¹ Knight Cancer Institute, Division of Hematology-Oncology, Oregon Health and Science University, Portland, Oregon.
² Department of Pathology, Oregon Health and Science University, Portland, Oregon.
³ Knight Cancer Institute, Division of Hematology-Oncology, Oregon Health and Science University, Portland, Oregon. Electronic address: tolba@oshu.edu.

PMID: 28502724
DOI: 10.1016/j.jtho.2017.04.025

No abstract available

Publication types

Case Reports

MeSH terms

Adenocarcinoma / genetics*
Adenocarcinoma / pathology
Adenocarcinoma of Lung
Adult
Afatinib
Gene Fusion / genetics*
Humans
Lung Neoplasms / genetics*
Lung Neoplasms / pathology
Male
Middle Aged
Neuregulin-1 / genetics*
Quinazolines / pharmacology
Quinazolines / therapeutic use*

Substances

NRG1 protein, human
Neuregulin-1
Quinazolines
Afatinib