Probable DRESS syndrome induced by IL-1 inhibitors

Orphanet J Rare Dis. 2017 May 11;12(1):87. doi: 10.1186/s13023-017-0645-x.

Abstract

Interleukin (IL)-1 inhibitors have been increasingly used for treating autoinflammatory diseases during the last 10 years, but the spectrum of their possible side effects is not yet fully known. Here, we bring physicians' attention to a new severe complication of IL-1 inhibitors, manifesting as a probable drug reaction with eosinophilia and systemic symptoms (DRESS) in two patients.

Keywords: Autoinflammatory disease; DRESS; IL-1 inhibitors.

Publication types

  • Letter
  • Comment

MeSH terms

  • Animals
  • Drug Hypersensitivity Syndrome / metabolism*
  • Drug Hypersensitivity Syndrome / pathology*
  • Female
  • Hereditary Autoinflammatory Diseases / metabolism*
  • Hereditary Autoinflammatory Diseases / pathology*
  • Histocompatibility Testing
  • Humans
  • Interleukin-1 / metabolism*
  • Receptors, Interleukin-1 / antagonists & inhibitors
  • Receptors, Interleukin-1 / metabolism*

Substances

  • Interleukin-1
  • Receptors, Interleukin-1