ADE-ing and Abetting Zika

Cell Host Microbe. 2017 May 10;21(5):557-558. doi: 10.1016/j.chom.2017.04.006.

Abstract

Although dengue virus (DENV) antibodies can neutralize or enhance Zika virus (ZIKV) infection in vitro, their contribution to ZIKV infection in vivo remains unclear. In a recent issue of Science, Bardina et al. (2017) explore the protective versus pathogenic roles of DENV-immune antibodies in ZIKV infection using a mouse model.

MeSH terms

  • Animals
  • Antibodies, Viral / immunology*
  • Dengue / immunology
  • Dengue / virology
  • Dengue Virus / immunology*
  • Dengue Virus / pathogenicity
  • Disease Models, Animal
  • Humans
  • Mice
  • Plasma / immunology
  • Zika Virus / immunology*
  • Zika Virus / pathogenicity
  • Zika Virus Infection / immunology*

Substances

  • Antibodies, Viral