Release of pancreatic secretory trypsin inhibitor from human hepatoblastoma cells on stimulation with cytokines

Life Sci. 1988;43(15):1233-40. doi: 10.1016/0024-3205(88)90213-5.

Abstract

To determine whether or not human pancreatic secretory trypsin inhibitor (PSTI) is an acute phase reactant released from hepatocytes, we investigated the effects of various cytokines on the release of PSTI from cultured human hepatoblastoma cells. PSTI was synthesized in human hepatoblastoma cells and released on stimulation with various cytokines: interleukin-1, tumor necrosis factor and interferon-beta.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Factors / pharmacology*
  • Carcinoma, Hepatocellular / metabolism*
  • Cytokines
  • Humans
  • Interferon Type I / pharmacology
  • Interleukin-1 / pharmacology
  • Liver Neoplasms
  • Pancreas / enzymology
  • Recombinant Proteins
  • Trypsin Inhibitors / metabolism*
  • Tumor Cells, Cultured
  • Tumor Necrosis Factor-alpha / pharmacology

Substances

  • Biological Factors
  • Cytokines
  • Interferon Type I
  • Interleukin-1
  • Recombinant Proteins
  • Trypsin Inhibitors
  • Tumor Necrosis Factor-alpha