Objective: To investigate serum adiponectin level in patients with Alzheimer's disease (AD) and its correlation with the patients' cognitive function.
Methods: This case-control study was conducted in 90 patients with a highly probable diagnosis ofAD, who were divided into mild, moderate and severe group saccording to the MMSE score. Ninety healthy subjects matched for age and gender with the AD patients were selected as the control group. The serum levels ofadiponectin in the participants were detected using enzyme-linked immunosorbent assay.
Results: Serum adiponectin level was significantly lower in the AD group than in the control group (P<0.05). Of the 3 subgroups of the AD patients, the moderate and severe AD groups showed significantly lower serum adiponectin level sthan the control group (P<0.05), but the difference in adiponectin levels was not significant between the mild AD group and the control group (P>0.05); serum adiponectin levels also differed significantly among the 3 subgroups of AD patients (P<0.05). Serum adiponectin level was positively correlated with the MMSE score in the AD patients (r=0.683, P<0.001).
Conclusion: Serum adiponectin levels are reduced in AD patients and associated with the degree of cognitive impairment.
目的: 探讨阿尔茨海默病患者血清脂联素水平及其与认知功能的关系。
方法: 采用病例对照研究方法，选取90例临床诊断很可能的阿尔茨海默病（AD）患者为AD组，并根据MMSE评分，将AD组分成轻、中、重3个亚组，选取年龄及性别相匹配的非AD健康体检者90例为对照组；通过酶联免疫吸附法分别检测AD组和对照组血清脂联素的水平。
结果: （1）AD组血清脂联素水平显著低于对照组，差异有统计学意义（P < 0.05）；AD组3个亚组的血清脂联素水平分别与对照组比较：中、重度AD组血清脂联素水平和对照组比较差异有统计学意义（P < 0.05），轻度AD组血清脂联素和对照组比较差异无明显统计学意义（P>0.05）；AD组3个亚组之间的血清脂联素水平两两比较差异有统计学意义（P < 0.05）；（2）AD患者血清脂联素水平与MMSE评分的相关分析示：血清脂联素水平与MMSE得分呈正相关性（r=0.683，P < 0.001）。
结论: 阿尔茨海默病患者血清脂联素水平降低；阿尔茨海默病患者血清脂联素水平可以反映认知功能损害的程度。