Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets

J Hepatol. 2017 Sep;67(3):603-618. doi: 10.1016/j.jhep.2017.04.009. Epub 2017 Apr 22.

Abstract

The majority of the human genome is not translated into proteins but can be transcribed into RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins, they contribute to diseases such as cancer. Here, we review examples of the functions of ncRNAs in liver cancer and their potential use for the detection and treatment of liver cancer.

Keywords: Cancer stem cell; Epithelial–to-mesenchymal transition; HCC; Hepatocellular carcinoma; Liver cancer; Long non-coding RNA; STAT3; Wnt; lncRNA; microRNA.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Biomarkers
  • Carcinoma, Hepatocellular / drug therapy
  • Carcinoma, Hepatocellular / genetics*
  • Epithelial-Mesenchymal Transition
  • Humans
  • Liver Neoplasms / drug therapy
  • Liver Neoplasms / genetics*
  • MicroRNAs / physiology
  • Neoplastic Stem Cells / physiology
  • RNA, Untranslated / physiology*
  • STAT3 Transcription Factor / physiology
  • Wnt Signaling Pathway / physiology

Substances

  • Biomarkers
  • MIRN122 microRNA, human
  • MicroRNAs
  • RNA, Untranslated
  • STAT3 Transcription Factor
  • STAT3 protein, human