Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment? T-Cell Heterogeneity, Plasticity, and Selection in Humans

Federica Sallusto; Antonino Cassotta; Daniel Hoces; Mathilde Foglierini; Antonio Lanzavecchia

doi:10.1101/cshperspect.a029421

Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment? T-Cell Heterogeneity, Plasticity, and Selection in Humans

Cold Spring Harb Perspect Biol. 2018 Mar 1;10(3):a029421. doi: 10.1101/cshperspect.a029421.

Authors

Federica Sallusto^{1

2}, Antonino Cassotta^{1

2}, Daniel Hoces¹, Mathilde Foglierini¹, Antonio Lanzavecchia¹

Affiliations

¹ Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
² Institute of Microbiology, ETH Zurich, 8093 Zurich, Switzerland.

Abstract

The wide range of effector and memory T cells is instrumental for immune regulation and tailored mechanisms of protection against pathogens. Here, we will focus on human CD4 T cells and discuss T-cell plasticity and intraclonal diversification in the context of a progressive and selective model of CD4 T-cell differentiation.

Publication types

Review

MeSH terms

CD4-Positive T-Lymphocytes / immunology
CD4-Positive T-Lymphocytes / physiology*
Cell Differentiation
Cell Plasticity*
Cellular Reprogramming
Humans
Immunologic Memory*