Linear immunoglobulin A dermatosis: A case report

Medwave. 2017 Apr 4;17(3):e6901. doi: 10.5867/medwave.2017.03.6901.
[Article in Spanish, English]

Abstract

We present the case of a sixty five year old woman with two months history of pruritus and hyperpigmented annular lesions on the trunk, buttocks and upper extremities. In addition, she presents vesicles with healthy skin on the basis, in the flexor aspect of wrists. No evidence of mucosal involvement. Histological study showed subepidermal vesicular dermatitis with inflammatory infiltrate of neutrophils and eosinophils. Direct immunofluorescence evidenced linear and continuous deposition of immunoglobulin A in basement membrane zone, compatible with linear immunoglobulin A disease.

En este texto se presenta el caso de una paciente de sesenta y cinco años con sintomatología de dos meses de evolución consistente en prurito y lesiones hiperpigmentadas anulares en tronco, glúteos y extremidades superiores. En el área flexora de las muñecas presenta vesículas sobre base eritematosa y piel sana, sin evidencia de compromiso mucoso. Al estudio histológico se constata dermatitis vesicular subepidérmica con infiltrado inflamatorio de neutrófilos y eosinófilos. La inmunofluorescencia directa muestra depósito lineal y continuo de inmunoglobulina A en zona de membrana basal, compatible con dermatosis por inmunoglobulina A lineal.

Keywords: bullous disease; linear IgA bullous dermatosis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Basement Membrane / immunology
  • Eosinophils / metabolism
  • Female
  • Fluorescent Antibody Technique, Direct / methods
  • Humans
  • Immunoglobulin A / immunology*
  • Linear IgA Bullous Dermatosis / diagnosis*
  • Linear IgA Bullous Dermatosis / immunology
  • Neutrophils / metabolism
  • Pruritus / immunology*

Substances

  • Immunoglobulin A