Malignant Rhabdoid Tumor of Soft Tissue

Pediatr Dev Pathol. 2017 Jun;20(3):262-266. doi: 10.1177/1093526617706814. Epub 2017 Apr 21.

Abstract

Introduction Malignant rhabdoid tumor (MRT) is defined as a high-grade sarcoma derived from an uncertain cell of origin. Its diagnosis is associated with poor prognosis and patient's life expectancy is greatly reduced. Material and method Here, we describe a unique case of 9-month-old boy who presented with a large MRT arising from the soft tissue of the neck. Following intensive multimodal treatment, the patient benefited from a 25 years' remission until the discovery of multiple liver metastases. Conclusion MRT of soft tissue needs to be distinguished from other soft tissue neoplasms, as MRT is highly aggressive and is usually associated with a poor outcome. In addition, this is the longest remission time reported in a patient with soft tissue MRT and this might be related to the use of early intensive multimodal treatments.

Keywords: SMARCB1/INI1; malignant rhabdoid tumor; oncology; pediatric; sarcoma; soft tissue tumor.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Head and Neck Neoplasms / pathology*
  • Head and Neck Neoplasms / therapy
  • Humans
  • Infant
  • Liver Neoplasms / diagnosis
  • Liver Neoplasms / secondary*
  • Male
  • Rhabdoid Tumor / diagnosis
  • Rhabdoid Tumor / secondary*
  • Rhabdoid Tumor / therapy
  • Soft Tissue Neoplasms / pathology*
  • Soft Tissue Neoplasms / therapy