Lighting-up breast cancer cells by a near-infrared fluorescent probe based on KIAA1363 enzyme-targeting

Chem Commun (Camb). 2017 Apr 27;53(35):4857-4860. doi: 10.1039/c7cc01798g.

Abstract

The first NIR KIAA1363-targeting probe, NB-AX, specifically and instantly featured an "off-on" switch upon gradual addition of KIAA1363 over all kinds of other biomolecules, and its detection limit was initially calculated to be 0.58 μg mL-1 (3δ/k). The probe was also able to be used in ultrafast distinguishing of breast cancer cells from normal cells in fluorescence imaging and applied in tissue imaging and tumor imaging in vivo.

MeSH terms

  • Breast Neoplasms / diagnostic imaging*
  • Carboxylic Ester Hydrolases / analysis*
  • Carboxylic Ester Hydrolases / metabolism
  • Female
  • Fluorescent Dyes / analysis*
  • Fluorescent Dyes / chemistry*
  • Humans
  • Models, Molecular
  • Molecular Structure
  • Optical Imaging*
  • Oxazines / chemistry*
  • Quantum Theory
  • Sterol Esterase

Substances

  • Fluorescent Dyes
  • Oxazines
  • Nile Blue
  • Carboxylic Ester Hydrolases
  • NCEH1 protein, human
  • Sterol Esterase