Acute masseter dystonia in a pediatric patient receiving aripiprazole and methylphenidate following induction of general anesthesia

Paediatr Anaesth. 2017 Aug;27(8):863-864. doi: 10.1111/pan.13154. Epub 2017 Apr 17.

Abstract

An 11-year-old male receiving aripiprazole, methylphenidate, and clonidine developed acute masseter dystonia inhibiting tracheal intubation after induction of general anesthesia with propofol and rocuronium. Following emergence, he had trismus and jaw discomfort. Psychiatry consultation suspected an acute dystonic reaction, so diphenhydramine was administered intravenously which resolved symptoms. We suspect chronic aripiprazole and methylphenidate usage combined with propofol administration in the short-term absence of methylphenidate made this patient susceptible to dystonic reactions.

Keywords: anesthesia induction; aripiprazole; dystonia; pediatrics; propofol; trismus.

Publication types

  • Case Reports

MeSH terms

  • Anesthesia, General
  • Antipsychotic Agents / adverse effects*
  • Appendectomy
  • Aripiprazole / adverse effects*
  • Central Nervous System Stimulants / adverse effects*
  • Child
  • Clonidine / adverse effects
  • Diphenhydramine / therapeutic use
  • Dystonia / chemically induced*
  • Histamine H1 Antagonists / therapeutic use
  • Humans
  • Male
  • Methylphenidate / adverse effects*
  • Trismus / chemically induced*
  • Trismus / drug therapy

Substances

  • Antipsychotic Agents
  • Central Nervous System Stimulants
  • Histamine H1 Antagonists
  • Methylphenidate
  • Aripiprazole
  • Diphenhydramine
  • Clonidine