Colistin-Resistant mcr-1-Positive Escherichia coli on Public Beaches, an Infectious Threat Emerging in Recreational Waters

Antimicrob Agents Chemother. 2017 Jun 27;61(7):e00234-17. doi: 10.1128/AAC.00234-17. Print 2017 Jul.

Abstract

The emergence and rapid spread of colistin-resistant Escherichia coli carrying the mcr-1 gene have generated an urgent need to strengthen surveillance. We performed a meticulous investigation of strains of this sort, which resulted in the identification of international clones of E. coli carrying IncX4-plasmid-mediated mcr-1 and blaCTX-M genes in recreational waters of public urban beaches in cities with high tourist turnover, highlighting a new environmental reservoir.

Keywords: Brazil; CTX-M; ESBL; IncX4; MCR-1; polymyxins.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Colistin / pharmacology*
  • Drug Resistance, Bacterial / genetics
  • Escherichia coli / drug effects*
  • Escherichia coli / genetics*
  • Escherichia coli Proteins / genetics
  • Escherichia coli Proteins / metabolism
  • Microbial Sensitivity Tests
  • Plasmids / genetics*
  • Polymyxins / pharmacology
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism

Substances

  • Anti-Bacterial Agents
  • Escherichia coli Proteins
  • Polymyxins
  • beta-Lactamases
  • Colistin