Systems approach to uncover signaling networks in primary immunodeficiency diseases

Jeff Choi; Rosemary Fernandez; Holden T Maecker; Manish J Butte

doi:10.1016/j.jaci.2017.03.025

Systems approach to uncover signaling networks in primary immunodeficiency diseases

J Allergy Clin Immunol. 2017 Sep;140(3):881-884.e8. doi: 10.1016/j.jaci.2017.03.025. Epub 2017 Apr 13.

Authors

Jeff Choi¹, Rosemary Fernandez², Holden T Maecker², Manish J Butte³

Affiliations

¹ School of Medicine, Stanford University, Stanford, Calif.
² Human Immune Monitoring Core, Stanford University, Stanford, Calif.
³ Department of Pediatrics, Division of Immunology, Allergy, and Rheumatology, University of California, Los Angeles, Calif. Electronic address: mbutte@mednet.ucla.edu.

Abstract

This broad, unbiased approach of studying signaling across all circulating immune cells in healthy subjects allowed identification of disrupted signaling networks in patients with primary immunodeficiencies.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Cytokines / immunology
Cytological Techniques
Humans
Immunologic Deficiency Syndromes / immunology*
STAT1 Transcription Factor / immunology
STAT3 Transcription Factor / immunology
Signal Transduction
Systems Biology
Young Adult

Substances

Cytokines
STAT1 Transcription Factor
STAT1 protein, human
STAT3 Transcription Factor
STAT3 protein, human

Grants and funding

R01 GM110482/GM/NIGMS NIH HHS/United States