The Molecular Revolution in Cutaneous Biology: The Era of Global Transcriptional Analysis

Andrew Johnston; Mrinal K Sarkar; Antonia Vrana; Lam C Tsoi; Johann E Gudjonsson

doi:10.1016/j.jid.2016.02.817

The Molecular Revolution in Cutaneous Biology: The Era of Global Transcriptional Analysis

J Invest Dermatol. 2017 May;137(5):e87-e91. doi: 10.1016/j.jid.2016.02.817.

Authors

Andrew Johnston¹, Mrinal K Sarkar¹, Antonia Vrana¹, Lam C Tsoi², Johann E Gudjonsson³

Affiliations

¹ Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
² Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
³ Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA. Electronic address: johanng@med.umich.edu.

PMID: 28411853
DOI: 10.1016/j.jid.2016.02.817

Abstract

In the 3 decades since the discovery of the polymerase chain reaction, a progression of remarkable technical advances has driven great strides in our understanding of molecular biology such that now we are able to study at once the entire and complete set of RNA transcripts that are produced by the genome. In this review, we describe the milestones that have led to this era of global transcriptional analysis, how these approaches have been extended towards skin disease, and their future directions.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Humans
Molecular Biology / trends*
Polymerase Chain Reaction / methods*
Skin Diseases / genetics*
Transcription, Genetic

Abstract

Publication types

MeSH terms

Grants and funding