Flavonoids isolated from Sinopodophylli Fructus and their bioactivities against human breast cancer cells

Chin J Nat Med. 2017 Mar;15(3):225-233. doi: 10.1016/S1875-5364(17)30039-0.

Abstract

Four prenylated flavonoids compounds 1-4, named sinopodophyllines A-D, and a flavonoid glycoside (compound 13), sinopodophylliside A, together with 19 known compounds (compounds 5-12 and 14-24) were isolated from the fruits of Sinopodophyllum hexandrum. The structures of new compounds were elucidated by extensive spectroscopic analysis, including HRESIMS, 1D and 2D NMR. Compounds 1-6, 9-11, and 14-17 were tested for their cytotoxicity against human breast-cancer T47D, MCF-7 and MDA-MB-231 cells in vitro, and compounds 2, 5, 6, 10 and 11 showed significant cytotoxicity (IC50 values < 10 μmol·L-1) against T47D cells.

Keywords: Breast-cancer cell lines; Flavonoid glycosides; Prenylated flavonoids; Sinopodophylli Fructus.

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Berberidaceae / chemistry*
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / physiopathology
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Flavonoids / chemistry
  • Flavonoids / isolation & purification
  • Flavonoids / pharmacology*
  • Fruit / chemistry
  • Humans
  • Molecular Structure

Substances

  • Antineoplastic Agents, Phytogenic
  • Flavonoids