IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity

Cristina Cunha; Samuel M Gonçalves; Cláudio Duarte-Oliveira; Luís Leite; Katrien Lagrou; António Marques; Carmen B Lupiañez; Inês Mesquita; Joana Gaifem; Ana Margarida Barbosa; Carlos Pinho Vaz; Rosa Branca; Fernando Campilho; Fátima Freitas; Dário Ligeiro; Cornelia Lass-Flörl; Jürgen Löffler; Manuel Jurado; Margarida Saraiva; Oliver Kurzai; Fernando Rodrigues; António G Castro; Ricardo Silvestre; Juan Sainz; Johan A Maertens; Egídio Torrado; Ilse D Jacobsen; João F Lacerda; António Campos Jr; Agostinho Carvalho

doi:10.1016/j.jaci.2017.02.034

IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity

J Allergy Clin Immunol. 2017 Sep;140(3):867-870.e9. doi: 10.1016/j.jaci.2017.02.034. Epub 2017 Apr 4.

Authors

Cristina Cunha¹, Samuel M Gonçalves¹, Cláudio Duarte-Oliveira¹, Luís Leite², Katrien Lagrou³, António Marques⁴, Carmen B Lupiañez⁵, Inês Mesquita¹, Joana Gaifem¹, Ana Margarida Barbosa¹, Carlos Pinho Vaz², Rosa Branca², Fernando Campilho², Fátima Freitas⁶, Dário Ligeiro⁷, Cornelia Lass-Flörl⁸, Jürgen Löffler⁹, Manuel Jurado⁵, Margarida Saraiva¹⁰, Oliver Kurzai¹¹, Fernando Rodrigues¹, António G Castro¹, Ricardo Silvestre¹, Juan Sainz⁵, Johan A Maertens¹², Egídio Torrado¹, Ilse D Jacobsen¹³, João F Lacerda¹⁴, António Campos Jr², Agostinho Carvalho¹⁵

Affiliations

¹ Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; ICVS/3B's PT Government Associate Laboratory, Braga/Guimarães, Portugal.
² Serviço de Transplantação de Medula Óssea, Instituto Português de Oncologia do Porto, Porto, Portugal.
³ Department of Microbiology and Immunology, KU Leuven-University of Leuven, Leuven, Belgium; Department of Laboratory Medicine and National Reference Center for Medical Mycology, University Hospitals Leuven, Leuven, Belgium.
⁴ Serviço de Imuno-Hemoterapia, Hospital de Braga, Braga, Portugal.
⁵ Genomic Oncology Area, GENYO, Center for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain; Hematology Department, Virgen de las Nieves University Hospital, Granada, Spain.
⁶ Instituto Português do Sangue e Transplantação, IP, Porto, Portugal.
⁷ Instituto Português do Sangue e Transplantação, IP, Lisbon, Portugal.
⁸ Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
⁹ Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.
¹⁰ i3S-Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal; IBMC-Instituto de Biologia Molecular e Celular, University of Porto, Porto, Portugal.
¹¹ Septomics Research Centre, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany.
¹² Department of Hematology, University Hospitals Leuven, Leuven, Belgium.
¹³ Research Group Microbial Immunology, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany.
¹⁴ Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisbon, Portugal; Serviço de Hematologia e Transplantação de Medula, Hospital de Santa Maria, Lisbon, Portugal.
¹⁵ Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; ICVS/3B's PT Government Associate Laboratory, Braga/Guimarães, Portugal. Electronic address: agostinhocarvalho@med.uminho.pt.

PMID: 28389392
DOI: 10.1016/j.jaci.2017.02.034

No abstract available

Publication types

Letter
Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aspergillosis / genetics*
Aspergillosis / immunology
Female
Genetic Predisposition to Disease*
Hematopoietic Stem Cell Transplantation
Humans
Interleukin-10 / genetics*
Leukocytes, Mononuclear / immunology
Macrophages / immunology
Male
Polymorphism, Single Nucleotide
Young Adult

Substances

IL10 protein, human
Interleukin-10