Rapid molecular diagnosis of the Mycobacterium tuberculosis Rangipo strain responsible for the largest recurring TB cluster in New Zealand

Claire V Mulholland; Ali Ruthe; Ray T Cursons; Robert Durrant; Noel Karalus; Kathryn Coley; James Bower; Elizabeth Permina; Megan J Coleman; Sally A Roberts; Vickery L Arcus; Gregory M Cook; Htin Lin Aung

doi:10.1016/j.diagmicrobio.2017.03.012

Rapid molecular diagnosis of the Mycobacterium tuberculosis Rangipo strain responsible for the largest recurring TB cluster in New Zealand

Diagn Microbiol Infect Dis. 2017 Jun;88(2):138-140. doi: 10.1016/j.diagmicrobio.2017.03.012. Epub 2017 Mar 23.

Authors

Affiliations

¹ School of Science, University of Waikato, Hamilton, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag, 92019, Auckland, New Zealand.
² School of Science, University of Waikato, Hamilton, New Zealand.
³ Computing & Mathematical Sciences, University of Waikato, Hamilton, New Zealand.
⁴ Department of Pathology, Waikato Hospital, Waikato District Health Board, Hamilton, New Zealand.
⁵ LabPlus, Auckland City Hospital, Auckland District Health Board, Auckland, New Zealand.
⁶ Otago Genomics and Bioinformatics Facility, University of Otago, Dunedin, New Zealand.
⁷ Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
⁸ LabPlus, Auckland City Hospital, Auckland District Health Board, Auckland, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag, 92019, Auckland, New Zealand.
⁹ Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag, 92019, Auckland, New Zealand.
¹⁰ Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag, 92019, Auckland, New Zealand. Electronic address: htin.aung@otago.ac.nz.

PMID: 28389146
DOI: 10.1016/j.diagmicrobio.2017.03.012

Abstract

Despite New Zealand being a low-tuberculosis (TB) burden country, there are disproportionately high rates of TB in particular populations. Here, we report a rapid molecular diagnosis of the Mycobacterium tuberculosis Rangipo strain responsible for the largest recurring TB cluster in New Zealand.

Keywords: Diagnostic; Māori; New Zealand; Tuberculosis; Whole-genome sequencing.

MeSH terms

Base Sequence
Cluster Analysis
Genome, Bacterial / genetics
Humans
Molecular Typing / methods*
Mycobacterium tuberculosis / classification*
Mycobacterium tuberculosis / genetics*
Mycobacterium tuberculosis / isolation & purification
New Zealand
Polymorphism, Single Nucleotide / genetics
Sequence Alignment
Tuberculosis, Pulmonary / diagnosis*
Tuberculosis, Pulmonary / microbiology