Two new cadinane-type sesquiterpenes, trichapargins A (1) and B (2), were isolated from cultures of the basidiomycete Trichaptum pargamenum. Their structures were elucidated on the basis of extensive spectroscopic methods. Trichapargin A showed weak activity to SW480 with an IC50 value of 24.8 μM.
Keywords: Trichaptum pargamenum; cadinane; cytotoxicity; structural elucidation.