Exploring the Link between the Germline and Somatic Genome in Cancer

Cancer Discov. 2017 Apr;7(4):354-355. doi: 10.1158/2159-8290.CD-17-0192.

Abstract

<b/> Carter and colleagues propose a systematic analysis of the germline and somatic genome in cancer. They identify interactions that occur between germline and somatic variants. This elucidates the function of the germline genome in the context of cancer risk and development. Cancer Discov; 7(4); 354-5. ©2017 AACRSee related article by Carter et al., p. 410.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Clonal Evolution / genetics*
  • Genome, Human*
  • Genome-Wide Association Study
  • Genomics
  • Germ-Line Mutation / genetics*
  • Humans
  • Mutation
  • Neoplasms / genetics*
  • Neoplasms / pathology