Risk factors, characteristics, and outcomes of candidemia in an adult intensive care unit in Turkey

Am J Infect Control. 2017 Jun 1;45(6):e61-e63. doi: 10.1016/j.ajic.2017.02.022. Epub 2017 Mar 27.

Abstract

Thirty-six patients with candidemia and 37 control patients were included consecutively to determine the characteristics of candidemia episodes. The patients with candidemia had higher mortality with higher Sequential Organ Failure Assessment scores and frequency of use of a central venous catheter, total parenteral nutrition, and broad-spectrum antibiotics; chronic renal failure with replacement therapy; and longer stay in an intensive care unit. Candida albicans was the predominant species followed by Candida glabrata, Candida tropicalis, and Candida parapsilosis. All isolates of C glabrata were itraconazole-resistant.

Keywords: Candida infection; Epidemiology; Mortality; Predisposing factors.

MeSH terms

  • Aged
  • Anti-Bacterial Agents / therapeutic use
  • Antifungal Agents / pharmacology
  • Candida / drug effects
  • Candida / isolation & purification
  • Candidemia / microbiology
  • Candidemia / mortality*
  • Central Venous Catheters / statistics & numerical data
  • Female
  • Humans
  • Intensive Care Units / statistics & numerical data*
  • Itraconazole / pharmacology
  • Length of Stay / statistics & numerical data
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Organ Dysfunction Scores
  • Parenteral Nutrition / statistics & numerical data
  • Renal Insufficiency / epidemiology
  • Renal Insufficiency / microbiology
  • Retrospective Studies
  • Risk Factors
  • Turkey / epidemiology

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Itraconazole