RECONsidering Sensing of Cyclic Dinucleotides

Jonathan Maelfait; Jan Rehwinkel

doi:10.1016/j.immuni.2017.03.005

RECONsidering Sensing of Cyclic Dinucleotides

Immunity. 2017 Mar 21;46(3):337-339. doi: 10.1016/j.immuni.2017.03.005.

Authors

Jonathan Maelfait¹, Jan Rehwinkel²

Affiliations

¹ Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
² Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK. Electronic address: jan.rehwinkel@imm.ox.ac.uk.

PMID: 28329697
DOI: 10.1016/j.immuni.2017.03.005

Abstract

Detection of cyclic dinucleotides (cdNs) by the STING pathway potently triggers the antiviral response. McFarland et al. now show that the mouse oxidoreductase RECON acts as a sensor for some bacterial cdNs, modulating innate signaling in a manner independent of STING to promote an antibacterial state.

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Comment

MeSH terms

Animals
Membrane Proteins*
Mice
Signal Transduction*

Substances

Membrane Proteins

Abstract

Publication types

MeSH terms

Substances

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