A novel framework for understanding reduced awareness of dyskinesias in Parkinson's Disease

Parkinsonism Relat Disord. 2017 Jun:39:58-63. doi: 10.1016/j.parkreldis.2017.03.009. Epub 2017 Mar 16.

Abstract

Background: Although dyskinesias-reduced-self-awareness (DRSA) in Parkinson's disease (PD) is related to deficit in metacognition, other factors, such as "Theory of Mind" (ToM), could operate.

Methods: Forty-one PD patients were assessed using the Global Awareness of Movement Disorders (GAM) and the Dyskinesias Subtracted-Index (DS-I). To study whether GAM and DS-I scores could be influenced by second-type ToM or Reading the Mind in the Eyes (RME) tasks, we conducted two multiple logistic regression analyses.

Results: The association between the GAM, the DS-I and RME task were highly significant. The association between DS-I and Trail Making Test B-A version was also verified.

Conclusion: DRSA was related with affective component of ToM and executive functions, thus caused by a complex interplay between specific neuropsychological and motor factors.

Keywords: Dyskinesias; Parkinson's disease; Reading the Mind in the Eyes; Self-awareness; Theory of Mind.

MeSH terms

  • Aged
  • Awareness / physiology*
  • Dyskinesia, Drug-Induced / etiology
  • Dyskinesia, Drug-Induced / psychology*
  • Executive Function / physiology*
  • Female
  • Humans
  • Levodopa / adverse effects
  • Male
  • Middle Aged
  • Neurologic Examination
  • Neuropsychological Tests
  • Parkinson Disease / complications
  • Parkinson Disease / drug therapy
  • Psychiatric Status Rating Scales
  • Regression Analysis
  • Theory of Mind / physiology*

Substances

  • Levodopa