Stabilizing the monomeric amyloid-β peptide by tyrocidine A prevents and reverses amyloidogenesis without the accumulation of oligomers

Chem Commun (Camb). 2017 Mar 30;53(27):3886-3889. doi: 10.1039/c7cc00506g.

Abstract

Amyloid-β (Aβ) oligomers are causative agents triggering AD pathogenesis, but their elimination remains challenging. We herein reported a natural cyclopeptide tyrocidine A prevents and reverses amyloidogenesis without Aβ oligomer accumulation by stabilizing the monomeric, but not the oligomeric state of Aβ peptides.

MeSH terms

  • Amyloid beta-Peptides / antagonists & inhibitors*
  • Amyloid beta-Peptides / chemistry
  • Amyloid beta-Peptides / metabolism
  • Dose-Response Relationship, Drug
  • Humans
  • Molecular Conformation
  • Protein Aggregates / drug effects
  • Protein Stability / drug effects
  • Tyrocidine / analogs & derivatives
  • Tyrocidine / chemistry
  • Tyrocidine / pharmacology*

Substances

  • Amyloid beta-Peptides
  • Protein Aggregates
  • Tyrocidine