Enabling Chemistry Technologies and Parallel Synthesis-Accelerators of Drug Discovery Programmes

Abstract

There is a pressing need to improve overall productivity in the pharmaceutical industry. Judicious investments in chemistry technologies can have a significant impact on cycle times, cost of goods and probability of technical success. This perspective describes some of these technologies developed and implemented at AbbVie, and their applications to the synthesis of novel scaffolds and to parallel synthesis.

Keywords: AbbVie chemistry technology; DRIFT; Electrochemistry; Flow chemistry; Flow photochemistry; Hazardous reagents in flow; High-temperature chemistry; High-throughput chemistry; LOPHTOR; Library design tool; Parallel synthesis; Phoenix; SWIFT; Synthetic methods.