Linear IgA and IgG bullous dermatosis

An Bras Dermatol. 2016 Sep-Oct;91(5 suppl 1):32-34. doi: 10.1590/abd1806-4841.20164630.

Abstract

Childhood linear immunoglobulin A dermatosis is a rare autoimmune vesiculobullous disease. It results in linear deposition of autoantibodies (immunoglobulin A) against antigens in the basal membrane zone, leading to subepidermal cleavage. Additional depositions of immunoglobulin G and complement-3 might occur. It is still debated whether concomitant findings of immunoglobulins A and G should be considered a subtype of this dermatosis or a new entity. Further studies are needed to recognize this clinical variant.

Publication types

  • Case Reports

MeSH terms

  • Basement Membrane / pathology
  • Biopsy
  • Child
  • Erythema / pathology
  • Fluorescent Antibody Technique, Direct
  • Humans
  • Linear IgA Bullous Dermatosis / pathology*
  • Male
  • Skin / pathology*
  • Skin Diseases, Vesiculobullous / pathology