Abstract
Systemic fungal infections pose insidious challenges in neonatal intensive care settings. We present the case of a 9-day-old male term neonate admitted for polymicrobial sepsis and hepatic dysfunction who later developed candidemia superinfection. Despite broad antifungal therapy, the fungemia was complicated by progressive growth of a fungus ball in the right ventricular outflow tract that threatened cardiac function. Surgical excision of the mass was undertaken by right atriotomy and histologic examination confirmed Candida albicans.
Keywords:
Candida albicans; acute liver failure; fungemia; human herpesvirus 1.
MeSH terms
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Antifungal Agents / therapeutic use
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Antiviral Agents / therapeutic use
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Candida albicans / growth & development*
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Candida albicans / isolation & purification
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Candidiasis / diagnosis
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Candidiasis / microbiology*
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Candidiasis / therapy
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Cardiac Surgical Procedures
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Echocardiography, Transesophageal
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Herpes Simplex / diagnosis
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Herpes Simplex / drug therapy
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Herpes Simplex / virology
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Herpesvirus 1, Human / isolation & purification
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Humans
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Infant, Newborn
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Infant, Newborn, Diseases / diagnosis
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Infant, Newborn, Diseases / microbiology*
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Infant, Newborn, Diseases / therapy
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Infant, Newborn, Diseases / virology
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Intensive Care Units, Neonatal
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Liver Failure / diagnosis
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Liver Failure / drug therapy
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Liver Failure / virology
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Male
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Superinfection*
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Treatment Outcome
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Ventricular Outflow Obstruction / diagnostic imaging
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Ventricular Outflow Obstruction / microbiology*
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Ventricular Outflow Obstruction / therapy
Substances
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Antifungal Agents
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Antiviral Agents