This paper addresses the problem of ensuring the validity and quality of data in ongoing multi-disciplinary studies where data acquisition spans several geographical sites. It describes an automated validation and quality control procedure that requires no user supervision and monitors data acquired from different locations before analysis. The procedure is illustrated for the Automated Prediction of Extubation readiness (APEX) project in preterm infants, where acquisition of clinical and cardiorespiratory data occurs at 6 sites using different equipment and personnel. We have identified more than 40 problems with clinical information and 25 possible problems with the cardiorespiratory signals. Our validation and quality control procedure identifies these problems in an ongoing manner so that they can be timely addressed and corrected throughout this long-term collaborative study.