Magnetic nanoparticles coated with cyclodextrins and citrate for irinotecan delivery

Ana P F Monteiro; Larissa D Caminhas; José D Ardisson; Roberto Paniago; Maria E Cortés; Rubén D Sinisterra

doi:10.1016/j.carbpol.2016.11.091

Magnetic nanoparticles coated with cyclodextrins and citrate for irinotecan delivery

Carbohydr Polym. 2017 May 1:163:1-9. doi: 10.1016/j.carbpol.2016.11.091. Epub 2016 Dec 2.

Authors

Ana P F Monteiro¹, Larissa D Caminhas¹, José D Ardisson², Roberto Paniago³, Maria E Cortés⁴, Rubén D Sinisterra⁵

Affiliations

¹ Chemistry Department, Exact Sciences Institute, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brazil.
² Centro de Desenvolvimento da Tecnologia Nuclear, Av. Presidente Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brazil.
³ Physical Department, Exact Science Institute, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brazil.
⁴ Restorative Dentistry Department, Faculty of Dentistry, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brazil.
⁵ Chemistry Department, Exact Sciences Institute, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brazil. Electronic address: sinisterra@ufmg.br.

PMID: 28267484
DOI: 10.1016/j.carbpol.2016.11.091

Abstract

In the present work, we study the role of different components in the formation of more stable iron oxide magnetic nanoparticles (MNPs): β-cyclodextrin (BCD), 2-hydroxypropyl-β-cyclodextrin (HP) and citrate anion. MNPs formulations were characterized by FTIR, particles size measurements, zeta potential based on dynamic light scattering principle technique, X-ray powder pattern diffraction, XPS spectroscopy, transmission electron microscopy and thermogravimetric analysis. The results showed that cyclodextrins and citrate plays a key role in order to obtain a lower size of coated MNPs and proved to be an efficient strategy to obtain a more stable colloidal dispersion, avoiding the nanoparticles oxidation, enhancing the irinotecan incorporation and release. Furthermore, citrate-coated BCD-MNPs showed the same cytotoxicity of the free IRI.

Keywords: Cancer; Citrate; Cyclodextrin; Irinotecan; Magnetic nanoparticle.