MRI ventilation abnormalities predict quality-of-life and lung function changes in mild-to-moderate COPD: longitudinal TINCan study

Miranda Kirby; Rachel L Eddy; Damien Pike; Sarah Svenningsen; Harvey O Coxson; Don D Sin; David G McCormack; Grace Parraga; Canadian Respiratory Research Network

doi:10.1136/thoraxjnl-2016-209770

MRI ventilation abnormalities predict quality-of-life and lung function changes in mild-to-moderate COPD: longitudinal TINCan study

Thorax. 2017 May;72(5):475-477. doi: 10.1136/thoraxjnl-2016-209770. Epub 2017 Mar 3.

Authors

Miranda Kirby¹, Rachel L Eddy^{2

3}, Damien Pike^{2

3}, Sarah Svenningsen^{2

3}, Harvey O Coxson¹, Don D Sin¹, David G McCormack⁴, Grace Parraga^{2

3}; Canadian Respiratory Research Network

Affiliations

¹ Centre for Heart Lung Innovation, University of British Columbia, Vancouver, Canada.
² Robarts Research Institute, The University of Western Ontario, London, Canada.
³ Department of Medical Biophysics, The University of Western Ontario, London, Canada.
⁴ Division of Respirology, Department of Medicine, The University of Western Ontario, London, Canada.

PMID: 28258250
DOI: 10.1136/thoraxjnl-2016-209770

Abstract

: COPD biomarkers are urgently required for clinical trials of new therapies. We evaluated the longitudinal change and relationship of MRI and CT biomarkers of COPD with St. George's Respiratory Questionnaire (SGRO) and FEV₁ worsening over 30 months. Among imaging biomarkers, only the longitudinal change in MRI ventilation defect percent (VDP) was greater in ever-smoker (n=34/p<0.05) and COPD (n=48/p<0.0001) subgroups compared with never-smokers (n=42). Only the longitudinal change in VDP was correlated with change in SGRQ (r=0.26/p=0.03), and only baseline VDP predicted longitudinal change in SGRQ>minimum clinically important difference (p=0.047) in mild-to-moderate COPD. These data strongly support the use of MRI intermediate endpoints in COPD studies.

Trial registration number: NCT02723474; Status: Recruiting.

Keywords: Emphysema; Imaging/CT MRI etc; Respiratory Measurement.

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Publication types

Letter

MeSH terms

Adult
Aged
Aged, 80 and over
Biomarkers / analysis
Disease Progression
Female
Humans
Longitudinal Studies
Magnetic Resonance Imaging / methods
Male
Middle Aged
Predictive Value of Tests
Prospective Studies
Pulmonary Disease, Chronic Obstructive / diagnostic imaging*
Pulmonary Disease, Chronic Obstructive / physiopathology*
Quality of Life*
Research Design
Respiratory Function Tests
Surveys and Questionnaires
Tomography, X-Ray Computed

Substances

Biomarkers

Associated data

ClinicalTrials.gov/NCT02723474