Abstract
Could improving the design of preclinical murine atherosclerosis studies help increase the success rate of cardiovascular clinical trials? In this Viewpoint, the authors advocate for a change from prevention to intervention study designs and rigorous lesion analyses which they argue will enhance the translational potential of murine atherosclerosis studies.
Keywords:
atherosclerosis; collagen; coronary disease; diabetes mellitus; myocardial infarction; smooth muscle; translational medical research.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anticholesteremic Agents / therapeutic use
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Atherosclerosis / etiology
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Atherosclerosis / prevention & control
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Atherosclerosis / therapy*
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Cell Lineage
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Cell Plasticity
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Disease Models, Animal
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Disease Progression
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Humans
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Hypercholesterolemia / complications
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Hypercholesterolemia / drug therapy
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Mice
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PCSK9 Inhibitors
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Plaque, Atherosclerotic / etiology
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Plaque, Atherosclerotic / pathology
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Research Design
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Rupture, Spontaneous
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Species Specificity
Substances
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Anticholesteremic Agents
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PCSK9 Inhibitors
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Pcsk9 protein, mouse