Objective: To investigate the association between waist circumference and risk of male lung cancer incidence. Methods: Since May 1, 2006, all the male employees including the retirees in Kailuan Group had been recruited into a Chinese Kailuan Male Cohort study. Information on anthropometries including body weight, height and waist circumference were collected at the baseline investigation, as well as information on newly-diagnosed lung cancer cases during the follow-up period. Waist circumference was grouped by quintiles of the population waist circumference distribution and categorized into the following five groups: <80, 80-, 85-, 90- and ≥95 cm, with the relevant normal group, the second quintile group (80-cm), serving as the referent category. Multivariable Cox proportional hazards regression models were used to evaluate the association between levels of waist circumference and risk of lung cancer. Results: A total of 105 386 males were recruited in the study, with 739 651.13 person-years of follow-up and an average follow-up period of 7.00 years. By the end of 2014, a total of 707 lung cancer cases were identified in the cohort study. Compared with males having the 80-cm of waist circumference, the hazard ratio (HR) and 95% confidence intervals (CI) of lung cancer were 1.17(0.90-1.52), 0.96(0.74-1.23), 0.94(0.72-1.21) and 0.80(0.63-1.03) for the <80, 85-, 90- and ≥95 cm of waist circumference, after adjustment for potential confounding factors including age, education level, smoking status and pack-year amount, alcohol consumption, physical activities, environment for working place and the prevalence on diabetes. The inverse association existed in smokers (≥95 cm compared to 80-cm of waist circumference: HR=0.69, 95%CI: 0.48-0.99) and alcohol drinkers (≥95 cm compared to 80-cm of waist circumference: HR=0.65, 95%CI: 0.45-0.94) when analysis was conducted in subgroups stratified by smoking or alcohol drinking status. Conclusion: Waist circumference might be inversely associated with male lung cancer risk.
目的：探讨腰围与男性肺癌发病风险的关系。 方法：以开滦集团全体在职及离退休男性职工为调查对象，自2006年5月建立开滦集团男性动态队列并随访。基线调查时收集研究对象身高、体重、腰围等信息，并在随访时收集结局事件信息。腰围按五分位数进行分组：<80、 80～、85～、90～、≥95 cm，并以腰围80~ cm组为参比组，采用多因素Cox比例风险回归模型分析腰围与男性肺癌发病的风险比（HR）和95%CI。 结果：截止2014年12月31日，共有105 386名研究对象进入队列，共随访739 651.13人年，平均随访7.00年，共收集肺癌新发病例707例。以80~ cm组为参比组，调整年龄、文化程度、吸烟状态、累计吸烟量、饮酒情况、体育锻炼、工作环境、糖尿病史后，腰围<80及85～、90～、≥95 cm组发生肺癌的HR值（95%CI）分别为1.17 (0.90~ 1.52）及0.96 （0.74~ 1.23）、0.94 （0.72~ 1.21）、0.80 (0.63~ 1.03），趋势检验P＝0.005。按吸烟、饮酒状态分层分析显示，腰围与肺癌发病风险在吸烟（腰围≥95 cm组与80~ cm组相比：HR＝0.69 ，95%CI： 0.48~ 0.99）、饮酒（腰围≥95 cm组与80~ cm组相比：HR＝0.65 ，95%CI：0.45~ 0.94）者中呈负相关。 结论：腰围可能与男性肺癌的发病风险之间有负相关关系。.
Keywords: Cohort studies; Lung neoplasms; Men; Prospective studies; Waist circumference.