The Dark Age(ing) of the Inflammasome

Konrad Aden; Philip Rosenstiel

doi:10.1016/j.immuni.2017.02.009

The Dark Age(ing) of the Inflammasome

Immunity. 2017 Feb 21;46(2):173-175. doi: 10.1016/j.immuni.2017.02.009.

Authors

Konrad Aden¹, Philip Rosenstiel²

Affiliations

¹ Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Rosalind-Franklin Str. 12, D-24105 Kiel, Germany.
² Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Rosalind-Franklin Str. 12, D-24105 Kiel, Germany. Electronic address: p.rosenstiel@mucosa.de.

PMID: 28228276
DOI: 10.1016/j.immuni.2017.02.009

Abstract

Mechanisms that contribute to healthy aging remain obscure. In a recent issue of Nature Medicine, Furman et al. (2017) describe that dietary caffeine inhibits the NLRC4 inflammasome, which is associated with disease-free aging.

Publication types

Comment

MeSH terms

Apoptosis Regulatory Proteins
Calcium-Binding Proteins
Humans
Inflammasomes*
Neuronal Apoptosis-Inhibitory Protein*

Substances

Apoptosis Regulatory Proteins
Calcium-Binding Proteins
Inflammasomes
Neuronal Apoptosis-Inhibitory Protein