Abstract
(±)-Uncarilins A and B (1a/1b and 2a/2b), two pairs of unusual dimeric isoechinulin-type enantiomers with a symmetric four-membered core, were isolated from Uncaria rhynchophylla driven by LCMS-IT-TOF analyses. Their structures were elucidated by extensive 1D and 2D NMR spectra, X-ray diffraction, and ECD spectroscopic data. (-)-Uncarilin B (2a) showed activities on MT1 and MT2 receptors with agonistic rates of 11.26% and 52.44% at a concentration of 0.25 mM.
MeSH terms
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Humans
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Indole Alkaloids / chemistry
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Indole Alkaloids / isolation & purification*
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Indoles
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Receptor, Melatonin, MT1 / agonists
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Receptor, Melatonin, MT2 / agonists
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Stereoisomerism
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Uncaria / chemistry*
Substances
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Drugs, Chinese Herbal
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Indole Alkaloids
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Indoles
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Receptor, Melatonin, MT1
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Receptor, Melatonin, MT2
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isoechinulin A