Vascular Morphogenesis: An Integrin and Fibronectin Highway

Hellyeh Hamidi; Johanna Ivaska

doi:10.1016/j.cub.2016.12.036

Vascular Morphogenesis: An Integrin and Fibronectin Highway

Curr Biol. 2017 Feb 20;27(4):R158-R161. doi: 10.1016/j.cub.2016.12.036.

Authors

Hellyeh Hamidi¹, Johanna Ivaska²

Affiliations

¹ Turku Centre for Biotechnology, University of Turku, FIN-20520 Turku, Finland.
² Turku Centre for Biotechnology, University of Turku, FIN-20520 Turku, Finland; Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland. Electronic address: johanna.ivaska@utu.fi.

PMID: 28222298
DOI: 10.1016/j.cub.2016.12.036

Abstract

A new study shows that endothelial cells use synaptic-like machinery to control polarized secretion and deposition of newly synthesised fibronectin. This process is coupled to active integrin recycling to the same locations and is fundamental for vascular development in zebrafish.

Publication types

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MeSH terms

Animals
Endothelial Cells
Fibronectins*
Integrins*
Morphogenesis
Zebrafish

Substances

Fibronectins
Integrins