Type Ⅱ innate lymphoid cells (ILC2) is a family of innate immune lymphocytes, which provide effective immune responses to cytokines. ILC2 are regulated by the nuclear transcription factor ROR alpha and GATA3, secreting cytokines IL-5 and IL-13, etc. Animal models have shown that ILC2 are involved in allergic diseases, such as asthma and atopic dermatitis, and also play a very important role in the metabolic balance. In addition, recent reports suggest that ILC2 not only play a role in the initial stages of the disease, but also can lead to chronic pathological changes in the disease, such as fibrosis, and may have an effect on acquired immunity. This paper mainly focus in the role and regulation of ILC2 cells, and review the research status of ILC2 in the field of chronic upper airway inflammatory diseases including allergic rhinitis and chronic rhinosinusitis.
Ⅱ型固有淋巴细胞(typeⅡinnate lymphoid cells，ILC2)属于天然免疫淋巴细胞家族的一个成员，它可以提供有效的免疫效应细胞因子，从而启动后续的免疫反应。ILC2受核转录因子RORα和GATA3的调控，分泌细胞因子白细胞介素(IL)5和IL-13等。动物实验模型证明，ILC2参与了变态反应性疾病，如哮喘和变应性皮炎，而且在代谢平衡中扮演了十分重要的角色。此外，最近的研究表明，ILC2不仅在疾病的初始阶段发挥作用，也可以导致疾病的慢性病理改变，如纤维化等，并可对获得性免疫产生影响。本文主要对ILC2细胞的作用、调控及其在变应性鼻炎(AR)和慢性鼻-鼻窦炎(CRS)等慢性上呼吸道炎性疾病中的研究现状进行综述。.
Keywords: Asthma; Rhinitis; Sinusitis; Type2 innate lymphoid cells.