Abstract
A murine model of zosteriform spread of herpes simplex virus to the eye is reported. Viral antigens were demonstrated by a peroxidase-antiperoxidase technique in the trigeminal ganglion, iris, ciliary body, and cornea. The histology suggested a spontaneous bacterial superinfection during the later stages of the herpetic disease of the cornea. The relevance to human disease is discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, Viral / analysis
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Ciliary Body / pathology
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Cornea / pathology
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Disease Models, Animal
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Eye / immunology
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Eye / pathology*
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Iris / pathology
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Keratitis, Dendritic / immunology
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Keratitis, Dendritic / pathology*
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Male
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Mice
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Mice, Inbred Strains
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Simplexvirus / immunology
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Time Factors
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Trigeminal Nerve / pathology