Dopamine and dopamine receptor D1 associated with decreased social interaction

Behav Brain Res. 2017 May 1:324:51-57. doi: 10.1016/j.bbr.2017.01.045. Epub 2017 Feb 13.

Abstract

Deficits in social interaction are hallmarks of neurological and psychiatric disorders. However, its underlying mechanism is still unclear. Here, we show that the loss of dendritic cell factor 1 (Dcf1) in the nervous system of mice induces social interaction deficiency, autism-like behaviour, and influences social interaction via the dopamine system. Dopamine receptor D1 agonist rescues this social cognition phenotype, and improves short-term plasticity. Together, this study presents a new genetic mechanism that affects social interaction and may provide a new way to improve positive social interaction and treat autism spectrum disorders.

Keywords: DA; DRD1; Dcf1; Social interaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / administration & dosage
  • Animals
  • Dopamine / administration & dosage
  • Dopamine / metabolism
  • Dopamine Agonists / administration & dosage
  • Excitatory Postsynaptic Potentials
  • Hippocampus / drug effects
  • Hippocampus / metabolism
  • Hippocampus / physiology
  • Interpersonal Relations*
  • Male
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology*
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / physiology*
  • Neuronal Plasticity
  • Receptors, Dopamine D1 / metabolism
  • Receptors, Dopamine D1 / physiology*

Substances

  • Dopamine Agonists
  • Membrane Proteins
  • Nerve Tissue Proteins
  • Receptors, Dopamine D1
  • Tmem59 protein, mouse
  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
  • Dopamine