Way out/way in: How the relationship between WRN and CDK1 may change the fate of collapsed replication forks

Valentina Palermo; Sara Rinalducci; Massimo Sanchez; Francesca Grillini; Annapaola Franchitto; Pietro Pichierri

doi:10.1080/23723556.2016.1268243

Way out/way in: How the relationship between WRN and CDK1 may change the fate of collapsed replication forks

Mol Cell Oncol. 2016 Dec 9;4(1):e1268243. doi: 10.1080/23723556.2016.1268243. eCollection 2017.

Authors

Valentina Palermo¹, Sara Rinalducci², Massimo Sanchez³, Francesca Grillini¹, Annapaola Franchitto⁴, Pietro Pichierri¹

Affiliations

¹ Section of Experimental and Computational Carcinogenesis, Department of Environment and Health, Istituto Superiore di Sanità , Rome, Italy.
² Proteomics Laboratory, Department of Ecology and Biology, Università della Tuscia , Viterbo, Italy.
³ Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità , Rome, Italy.
⁴ Section of Molecular Epidemiology, Department of Environment and Health, Istituto Superiore di Sanità , Rome, Italy.

Abstract

Replication-dependent double-strand breaks (DSBs) are the main source of genomic instability as their inaccurate repair stimulates chromosomal rearrangements. In a recent work, we uncover a novel regulatory circuit that involves the Werner's syndrome helicase and CDK1, and that is essential for repair pathway choice at replication-dependent DSBs.

Keywords: DNA repair; WRN protein; end-resection.