Absence of association between gallstone and coronary artery calcification

Atherosclerosis. 2017 Mar:258:51-55. doi: 10.1016/j.atherosclerosis.2017.01.035. Epub 2017 Feb 1.

Abstract

Background and aims: Gallstone has been suggested to be associated with cardiovascular disease (CVD). Coronary artery calcification (CAC) is an excellent value to predict future CVD. The aim of this study was to evaluate the association between gallstone and CAC.

Methods: Data were analyzed from an occupational cohort of 46,893 subjects (37,557 men and 9336 women) between 2011 and 2014. Participants with cancer or CVD histories or missing data at baseline were excluded from the study. Gallstone was diagnosed by ultrasound-documentation. Multivariate logistic analysis was conducted to examine the relationship between gallstone and CAC.

Results: The total population who had gallstone was 1426 (3.1%). In multivariate analysis, odds ratios (OR) for gallstone were not different according to CAC score groups in men and women. In addition, gallstone was not associated with higher OR for CAC in men and women.

Conclusions: Gallstone was not associated with CAC in both Korean men and women.

Keywords: Coronary artery calcification; Correlation; Gallstone; Risk factors.

MeSH terms

  • Adult
  • Computed Tomography Angiography
  • Coronary Angiography / methods
  • Coronary Artery Disease / diagnostic imaging
  • Coronary Artery Disease / epidemiology*
  • Cross-Sectional Studies
  • Female
  • Gallstones / diagnostic imaging
  • Gallstones / epidemiology*
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Odds Ratio
  • Republic of Korea / epidemiology
  • Retrospective Studies
  • Risk Factors
  • Ultrasonography
  • Vascular Calcification / diagnostic imaging
  • Vascular Calcification / epidemiology*