Microglial Barriers to Viral Gene Delivery

Neuron. 2017 Feb 8;93(3):468-470. doi: 10.1016/j.neuron.2017.01.025.

Abstract

In this issue of Neuron, Tufail et al. present an underlying mechanism for microglia-mediated elimination of virally transduced cells in the central nervous system. These findings could contribute to the development of improved gene therapies for various neurological disorders by exploring why microglia destroy viable cells following viral infection.

MeSH terms

  • Central Nervous System*
  • Gene Transfer Techniques
  • Genetic Therapy
  • Humans
  • Microglia*
  • Neurons