Comparison of two-risk assessment algorithms for preeclampsia in first trimester with consecutive intake of low-dose aspirin in the high-risk group - an observational study

J Matern Fetal Neonatal Med. 2018 Mar;31(5):549-552. doi: 10.1080/14767058.2017.1291621. Epub 2017 Mar 3.

Abstract

We analyzed outcome of women screened for preeclampsia with two different multifactorial risk algorithms (Predictor®Software by PerkinElmer, PerkinElmer, Waltham, MA; PERK-group: n = 214 and Viewpoint® by GE Healthcare, Dornstadt, Germany; VIEW-group: n = 209) in first trimester. Women at high risk for developing preeclampsia were advised to take low-dose acetylsalicylic acid (LDA). Screening positive rates for early onset preeclampsia differed significantly between the two groups (7.9% versus 26.3%; p = 0.000). According the clinical use of screening test criteria, LDA was prescribed in 63 (29.4%) women in the PE-group and 55 (26.3%) in the VP-group (p = 0.516). There were no differences in onset of preeclampsia [4 (1.9%) versus 6 (2.9%); p = 0.540]. No early or severe preeclampsia occurred in the whole population.

Keywords: Preeclampsia; aspirin; first-trimester screening; low-dose acetylsalicylic acid.

Publication types

  • Comparative Study
  • Observational Study

MeSH terms

  • Algorithms*
  • Aspirin / administration & dosage*
  • Aspirin / therapeutic use
  • Decision Support Techniques*
  • Female
  • Humans
  • Platelet Aggregation Inhibitors / administration & dosage*
  • Platelet Aggregation Inhibitors / therapeutic use
  • Pre-Eclampsia / diagnosis*
  • Pre-Eclampsia / prevention & control
  • Pregnancy
  • Pregnancy Trimester, First*
  • Retrospective Studies
  • Risk Assessment
  • Risk Factors
  • Treatment Outcome

Substances

  • Platelet Aggregation Inhibitors
  • Aspirin