When LIN41 Comes to a Fork in the Road, It Takes BOTH Paths: Translational Repression OR mRNA Decay, Depending on the Target Site Position

Jacqelyn M Hand; Ariel A Bazzini

doi:10.1016/j.molcel.2017.01.018

When LIN41 Comes to a Fork in the Road, It Takes BOTH Paths: Translational Repression OR mRNA Decay, Depending on the Target Site Position

Mol Cell. 2017 Feb 2;65(3):375-377. doi: 10.1016/j.molcel.2017.01.018.

Authors

Jacqelyn M Hand¹, Ariel A Bazzini²

Affiliations

¹ Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA.
² Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA; Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA. Electronic address: arb@stowers.org.

PMID: 28157501
DOI: 10.1016/j.molcel.2017.01.018

Abstract

In this issue, Aeschimann et al. (2017) demonstrate that, depending on the target location site (5'UTR or 3'UTR), LIN41 triggers repression of translation or mRNA decay, suggesting that one factor may use two independent pathways of post-transcriptional gene regulation.

Keywords: RNA-binding protein; early development; gene regulation; mRNA decay; translation repression.

MeSH terms

3' Untranslated Regions
5' Untranslated Regions
Animals
Gene Expression Regulation
Humans
Protein Biosynthesis*
RNA Stability
RNA, Messenger / chemistry
RNA, Messenger / metabolism*
Transcription Factors / metabolism*

Substances

3' Untranslated Regions
5' Untranslated Regions
RNA, Messenger
Transcription Factors