Bayesian approach to decompression sickness model parameter estimation

Comput Biol Med. 2017 Mar 1:82:3-11. doi: 10.1016/j.compbiomed.2017.01.006. Epub 2017 Jan 17.

Abstract

We examine both maximum likelihood and Bayesian approaches for estimating probabilistic decompression sickness model parameters. Maximum likelihood estimation treats parameters as fixed values and determines the best estimate through repeated trials, whereas the Bayesian approach treats parameters as random variables and determines the parameter probability distributions. We would ultimately like to know the probability that a parameter lies in a certain range rather than simply make statements about the repeatability of our estimator. Although both represent powerful methods of inference, for models with complex or multi-peaked likelihoods, maximum likelihood parameter estimates can prove more difficult to interpret than the estimates of the parameter distributions provided by the Bayesian approach. For models of decompression sickness, we show that while these two estimation methods are complementary, the credible intervals generated by the Bayesian approach are more naturally suited to quantifying uncertainty in the model parameters.

Keywords: Bayesian; Decompression illness; Decompression model; Decompression sickness; Markov-Chain-Monte-Carlo.

MeSH terms

  • Bayes Theorem
  • Computer Simulation
  • Decompression Sickness / epidemiology*
  • Decompression Sickness / physiopathology*
  • Diving / statistics & numerical data*
  • Humans
  • Likelihood Functions
  • Models, Biological*
  • Models, Statistical*
  • Nitrogen / blood*
  • Oxygen / blood*
  • Prevalence
  • Prognosis
  • Proportional Hazards Models
  • Reproducibility of Results
  • Risk Assessment / methods
  • Risk Factors
  • Sensitivity and Specificity

Substances

  • Nitrogen
  • Oxygen