Damaged reward areas in human alcoholics: neuronal proportion decline and astrocyte activation

Acta Neuropathol. 2017 Mar;133(3):485-487. doi: 10.1007/s00401-017-1675-0. Epub 2017 Jan 17.

Authors

Daniil Sarkisyan¹, Igor Bazov², Hiroyuki Watanabe², Olga Kononenko², Ann-Christine Syvänen³, Gunter Schumann⁴, Tatiana Yakovleva², Georgy Bakalkin²

Affiliations

¹ Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Box 591, BMC Husargatan 3, SE-75124, Uppsala, Sweden. daniil.sarkisyan@farmbio.uu.se.
² Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Box 591, BMC Husargatan 3, SE-75124, Uppsala, Sweden.
³ Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
⁴ Institute of Psychiatry, King's College London, London, UK.

PMID: 28097436
DOI: 10.1007/s00401-017-1675-0

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Alcoholics
Alcoholism / metabolism
Alcoholism / pathology*
Analysis of Variance
Antigens, Nuclear / metabolism
Astrocytes / metabolism
Astrocytes / pathology*
Cell Count
Cohort Studies
Glial Fibrillary Acidic Protein / metabolism
Humans
Male
Nerve Tissue Proteins / metabolism
Neurons / metabolism
Neurons / pathology*
Nucleus Accumbens / metabolism
Nucleus Accumbens / pathology*
Prefrontal Cortex / metabolism
Prefrontal Cortex / pathology*
RNA, Messenger / metabolism
Reward
White People

Substances

Antigens, Nuclear
Glial Fibrillary Acidic Protein
Nerve Tissue Proteins
RNA, Messenger
neuronal nuclear antigen NeuN, human