Ductal Carcinoma in situ Detected during Prospective MR Imaging Screening of a Woman with a BRCA2 Mutation: The First Case Report in Japan

Magn Reson Med Sci. 2017 Jul 10;16(3):265-269. doi: 10.2463/mrms.cr.2016-0090. Epub 2017 Jan 13.

Abstract

The present case is the first report in Japan in which a breast cancer was discovered as a result of prospective magnetic resonance imaging (MRI) screening study for BRCA1/2 mutation carriers who were free of breast or ovarian cancer. This case is significant and it verifies the importance of MRI screening in breast or ovarian cancer-free BRCA1/2 mutation carriers who do not exhibit positive mammographic or ultrasonographic findings.

Keywords: BRCA2; ductal carcinoma in situ; hereditary breast and ovarian cancer syndrome; magnetic resonance imaging.

Publication types

  • Case Reports

MeSH terms

  • Breast Neoplasms / diagnostic imaging*
  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology*
  • Carcinoma, Intraductal, Noninfiltrating / diagnostic imaging*
  • Female
  • Genes, BRCA1
  • Genes, BRCA2
  • Genetic Predisposition to Disease*
  • Genetic Testing / methods*
  • Humans
  • Japan
  • Magnetic Resonance Imaging / methods*
  • Middle Aged
  • Mutation
  • Prospective Studies