Building a Beautiful Beast: Mammalian Respiratory Complex I

Adela M Guaras; José Antonio Enríquez

doi:10.1016/j.cmet.2016.12.019

Building a Beautiful Beast: Mammalian Respiratory Complex I

Cell Metab. 2017 Jan 10;25(1):4-5. doi: 10.1016/j.cmet.2016.12.019.

Authors

Adela M Guaras¹, José Antonio Enríquez²

Affiliations

¹ Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain.
² Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain. Electronic address: jaenriquez@cnic.es.

PMID: 28076765
DOI: 10.1016/j.cmet.2016.12.019

Abstract

Understanding the mammalian respiratory complex I assembly has been an arduous task due to the lack of appropriate techniques and the complexity of the process. In this issue, a new tour de force based on complexome profiling provides an encyclopedic description of the process (Guerrero-Castillo et al., 2017).

Keywords: OXPHOS; assembly; complex I; mitochondria; respiratory complexes; supercomplexes.

Publication types

Comment

MeSH terms

Animals
Electron Transport Complex I*
Humans
Mitochondria
Oxidative Phosphorylation*

Substances

Electron Transport Complex I